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The principal cytochrome P450 isoenzyme concerned seems to become CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Close to 85% of the oral dose appears within the urine inside 24 hrs of administration, most as the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information and fact